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To see how iVexSol’s Intelligent Manufacturing™ can provide time-saving solutions to enable your clinical development, select your current stage.

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Preclinical
Phase I
Phase II
Late Phase - Launch

Lentiviral vectors, though maintaining an outstanding safety record and being used in hundreds of clinical trials, have been limited by traditional production methods.

The result: Long wait times, skyrocketing cost of goods and chronic vector shortages.

What if there was a better way?

Meet iVexSol’s Intelligent ManufacturingTM

How does it work?

iVexSol’s next-generation stable lentiviral vector production platform begins with the generation of a clonally-derived master cell bank of stable vector-producing cells for the production of your gene of interest.

3

Transduction

Serum-free, suspension host cells are engineered with microgram quantities of plasmid

2

Plasmid Engineering

Plasmids are linearized and re-engineered to include inducible constructs.

1

Vector Fitness Testing

We begin by fitness testing your current platform to ensure it is fit for purpose.

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4

Selection

Cells are seeded, expanded, and screened in to identify highly productive clones.

5

Optimal Producer

Optimal producers are further screened for stability, functionality and safety.

6

MCB Generation

Optimal clones are expanded to create a Master Cell Bank.

7

Long Term Storage

MCB is cryopreserved and split 50/50 for off-site storage.

1

Vector Fitness Testing

We begin by fitness testing your current platform to ensure it is fit for purpose.

2

Plasmid Engineering

Plasmids are linearized and re-engineered to include inducible constructs.

3

Transduction

Serum-free, suspension host cells are engineered with microgram quantities of plasmid

4

Selection

Cells are seeded, expanded, and screened in to identify highly productive clones.

5

Optimal Producer

Optimal producers are further screened for stability, functionality and safety.

6

MCB Generation

Optimal clones are expanded to create a Master Cell Bank.

7

Long Term Storage

MCB is cryopreserved and split 50/50 for off-site storage.

Then, whether it be your initial production run or a subsequent run, each time you need more vector, we simply expand a vial from your bank, harvest and cryopreserve the precise amount of vector you require and then send it to you (or anywhere else in the world). On demand: All within weeks, not months of your order.

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Vector “On Demand”

How does it impact my program?

Our Intelligent Manufacturing TM ensures the rapid and reliable production of high quality, high-titer, “ready to use” vector on time and at any scale, accelerating your clinical development timeline.

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