Help Us Customize Your Journey

To see how iVexSol’s Intelligent Manufacturing™ can provide time-saving solutions to enable your clinical development, select your current stage.

Thank you.

Lentiviral vectors, though maintaining an outstanding safety record and being used in hundreds of clinical trials, have been limited by traditional production methods.

The result: Long wait times, skyrocketing cost of goods and chronic vector shortages.

What if there was a better way?


Meet iVexSol’s Intelligent ManufacturingTM

How does it work?

iVexSol’s next-generation stable lentiviral vector production platform begins with the generation of a clonally-derived master cell bank of stable vector-producing cells for the production of your gene of interest.

3

Transduction

Serum-free, suspension host cells are engineered with microgram quantities of plasmid

2

Plasmid Engineering

Plasmids are linearized and re-engineered to include inducible constructs.

1

Vector Fitness Testing

We begin by fitness testing your current platform to ensure it is fit for purpose.

Group 722 Group 723 Group 724 Group 725 Path 1370 Group 726 Group 727
4

Selection

Cells are seeded, expanded, and screened in to identify highly productive clones.

5

Optimal Producer

Optimal producers are further screened for stability, functionality and safety.

6

MCB Generation

Optimal clones are expanded to create a Master Cell Bank.

7

Long Term Storage

MCB is cryopreserved and split 50/50 for off-site storage.

1

Vector Fitness Testing

We begin by fitness testing your current platform to ensure it is fit for purpose.

2

Plasmid Engineering

Plasmids are linearized and re-engineered to include inducible constructs.

3

Transduction

Serum-free, suspension host cells are engineered with microgram quantities of plasmid

4

Selection

Cells are seeded, expanded, and screened in to identify highly productive clones.

5

Optimal Producer

Optimal producers are further screened for stability, functionality and safety.

6

MCB Generation

Optimal clones are expanded to create a Master Cell Bank.

7

Long Term Storage

MCB is cryopreserved and split 50/50 for off-site storage.

Then, whether it be your initial production run or a subsequent run, each time you need more vector, we simply expand a vial from your bank, harvest and cryopreserve the precise amount of vector you require and then send it to you (or anywhere else in the world). On demand: All within weeks, not months of your order.

brand icon

Vector “On Demand”

How does it impact my program?

Our Intelligent Manufacturing TM ensures the rapid and reliable production of high quality, high-titer, “ready to use” vector on time and at any scale, accelerating your clinical development timeline.

ivexsol-vector-on-demand

SUBSCRIBE!

Get the latest iVexSol updates

Mask Group 1

Want more information?

Or let us know where you are in your clinical development to learn more about how our solutions can help you now.